Royal Columbian Hospital and Eagle Ridge Hospital

Biomarker Lactate Assessment of Shock in Trauma - BLAST

The primary aim of the BLAST study is to compare prehospital lactate levels to systolic blood pressure less than or equal to 90mmHg in ability to predict the need for resuscitative care to treat shock caused by hemorrhage following traumatic injury.

This observational study involves the testing of whole blood lactate during out-of-hospital emergency care and repeated testing upon arrival in the hospital’s emergency department using a point of care meter. Blood sampling will be done using a drop of blood discarded in the process of an intravenous catheter insertion by the paramedics at the scene of the incident. The second sample will be obtained during the process of admission lab work blood draws. This has been determined to be a minimal risk study and has been granted a waiver of informed consent.

Patient outcomes to be measured are resuscitative care defined as the administration of packed red blood cells, emergent intervention for hemorrhage control using thoracotomy, laparotomy, pelvic fixation or interventional radiologic control of hemorrhage or death within 6 hours of arrival in the emergency department for patients with prehospital systolic blood pressures greater than 70 but less than or equal to 100.

The secondary aim is to evaluate the usefulness of point of care lactate when combined with other prehospital variables (age, heart rate, systolic blood pressure, Glasgow Coma Score, mechanism of injury) in predicting the need for resuscitative care.

(copied from the ROC website) Click here to be taken to the ROC website.